IN VITRO ASSESSMENT OF THE ANTHELMINTIC ACTIVITY OF COPPER OXIDE AND ZINC OXIDE NANOPARTICLES ON EGG AND ADULT STAGES OF FASCIOLA HEPATICA: EVIDENCE ON OXIDATIVE STRESS BIOMARKERS, AND DNA DAMAGE

Abstract Objectives Fasciolosis is Water Pumps of significant economic and public health importance worldwide.The lack of a successful vaccine and emerging resistance in flukes to the drug of choice, triclabendazole, has initiated the search for alternative approaches.In recent years, metallic nanoparticles have been extensively investigated for th

The germinal center (GC) reaction is a key feature of adaptive humoral immunity.GCs represent the site where mature B cells refine their B-cell receptor (BCR) and are selected based on the newly acquired affinity for the antigen.In the GC, B cells undergo multiple cycles of proliferation, BCR remodeling by immunoglobulin somatic hypermutation (SHM)

Abstract A full understanding of the inactivated COVID-19 vaccine-mediated antibody responses to SARS-CoV-2 circulating variants will inform vaccine effectiveness and vaccination development strategies.Here, we offer insights into the inactivated vaccine-induced antibody responses after prime-boost vaccination at both the polyclonal and monoclonal

Enzyme assisted extraction was used to extract the polysaccharides from pumpkin seeds (PSP) Hoof Clippers and the extraction parameters were optimized by response surface methodology (RSM).Under the optimum experimental parameters: Extraction temperature of 60 °C, extraction time of 43 min, enzyme concentration of 2.5%, and pH of 6.0, the yield

Fatigue reliability assessment of welded joints can consider the uncertainties from various sources and can establish the design criteria and inspection plans.The present paper aims to address the uncertainties explicitly.The notch strain approach that accounts for the effects of the misalignment, local notch, and crack-like imperfection, which is